First thing:

There is no such thing as a "macro", from the computer's perspective. It only knows that a verb is being used, it doesn't know or care how it was used, and there's no way to make it care.

The problem in games isn't that people use macros... it's that they ABUSE them. You don't want people able to attack a hundred times a second? WRITE YOUR CODE SO THEY CAN'T. It won't matter if they enter the attack verb a hundred times a second if your code only recognizes it once every five seconds. If your game is well-coded, people can use all the macros they want and not screw anything up.