A good example is Xirres hosting app using port 6000
http://www.byond.com/play/93631247
If you watch Console you'll see the error
Failed to load resource: net::ERR_UNSAFE_PORT
http://X.X.X.X:6000/play
The only way to bypass this on Chrome is to set --explicitly-allowed-ports=xxx on the shortcut's "target"
Some light reading,
http://superuser.com/questions/188006/ how-to-fix-err-unsafe-port-error-on-chrome-when-browsing-to- unsafe-ports
https://jazzy.id.au/2012/08/23/ why_does_chrome_consider_some_ports_unsafe.html
My advice is to choose common well known ports to host with.